Formulation, optimization, and pharmacodynamic evaluation of
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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder in which the death of brain cells causes memory loss and cognitive decline, consequently affecting the quality of life of the patients.Cholinergic neurotransmission loss is the main cause of cognitive impairment in patients with Alzheimer’s disease. Phospholipids (PLs) play an essential role in memory and learning abilities. Moreover, PLs act as a source of choline in acetylcholine synthesis. This study aimed to prepare and optimize the formulation of chitosan/phospholipid/?-cyclodextrin (CTS/PL/?-CD) microspheres that can improve cognitive impairment......

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734723/
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