Frailty Increases Post-Heart Transplantation Death, Hospital
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Frailty is prevalent in the patients with advanced heart failure; however, its impact on clinical outcomes after heart transplantation (HTx) is unclear. The aim of this study was to assess the impact of pre-transplant frailty on mortality and the duration of hospitalization after HTx.

We retrospectively reviewed the post-transplant outcomes of 140 patients with advanced heart failure who had undergone frailty assessment within the 6-month interval before HTx: 43 of them were frail (F) and 97 were non-frail (NF).

Results:
-- Post-transplant survival rates for the NF cohort at 1 and 12 months were 97% and 95%, respectively.

-- In contrast, post-transplant survival rates for the F cohort at the same time points were 86% and 74%, respectively.

-- The Cox proportional hazards regression analysis demonstrated that pre-transplant frailty was an independent predictor of post-transplant mortality with a hazard ratio of 3.8.

-- Intensive care unit and hospital length of stay were 2 and 7 days longer in the F cohort, respectively, than in the NF cohort.

Conclusively, Frailty within 6 months before HTx is independently associated with increased mortality and prolonged hospitalization after transplantation. Future research should focus on the development of strategies to mitigate the adverse effects of pre-transplant frailty.

Source: https://www.jhltonline.org/article/S1053-2498(20)31839-8/fulltext
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