Freeze-Dried Amniotic Membranes in Corneal Ulcers Treated by
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The purpose of this study was to assess cryopreserved amniotic membrane (C-AM) versus chorion-free freeze-dried amniotic membrane (FD-AM) overlay transplantation for corneal ulcers.

When C-AMs were not available because of the COVID-19 pandemic, 28 corneal ulcers underwent FD-AM overlay transplantation and were retrospectively compared with 22 corneal ulcers treated with C-AM during the same period. All patients had at least 3 months of follow-up. Ulcers were assessed at baseline and then at 72 hours, 1 month, and 3 months. Population demographics, follow-up time, ulcer etiologies, epithelial defect size, ulcer depth, and complications were also recorded.

Results:
--Baseline characteristics and clinical features of both groups were comparable. There was no statistically significant difference in the number of overlay AM transplantations or early detachments.

--At 3 months, the corneal healing rate was almost the same in both groups (89% and 91% for FD-AM and C-AM, respectively).

--Complications were equally uncommon (11% and 9%, respectively).

--In logistic regression, the type of the membrane did not influence corneal healing at 1 month or 3 months, regardless of the depth of the ulcer. However, whatever the type of AM used, the deeper the ulcer was, the less likely it was to heal at 3 months.

This study gives a favourable view of the efficacy of FD-AM compared to C-AM when utilized in corneal ulcers as an overlay transplant.

Source: https://journals.lww.com/corneajrnl/Abstract/9000/Freeze_Dried_Versus_Cryopreserved_Amniotic.95717.aspx
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