Gastrectomy for Gastric Cancer associated with Weight Loss,
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Gastric cancer patients with diabetes who undergo conventional gastrectomy have an increased likelihood of diabetes remission with greater postoperative weight loss, independent of baseline weight, a recent study suggests.

This study included 5,150 patients with diabetes who underwent gastrectomy for cancer from 2004 to 2014. Diabetes remission was defined in 3 ways, according to postoperative antidiabetic medication and fasting plasma glucose (FPG) levels. Diabetes relapse was defined as reinitiating antidiabetic medication among patients in diabetes remission.

--Six predictors (higher BMI, total gastrectomy, younger age, FPG levels, number of oral hypoglycemic agents [OHAs], and no insulin use) of diabetes remission increased the likelihood of remission by >13-fold.

--Three factors (younger age, lower FPG levels, and use of only 1 OHA) predicted a 58% decreased likelihood of diabetes relapse.

--The lowest interval of postoperative BMI decrease showed a >3-fold increased likelihood of diabetes remission than the highest interval, independent of baseline BMI.

Conclusively, the variables significantly predict diabetes remission and relapse after gastrectomy for cancer. Greater postoperative weight decrease may increase the likelihood of diabetes remission, independent of baseline weight.

Journal of The American College of Surgeons
Source: https://doi.org/10.1016/j.jamcollsurg.2021.03.019
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