Gastroesophageal reflux disease increases the risk of laryng
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Results of a large study indicate that gastroesophageal reflux disease (GERD) is linked with increased risks of various carcinomas of the larynx and esophagus. The study was published in the journal Cancer.

Investigators prospectively examined the association between GERD and esophageal adenocarcinoma (EADC), esophageal squamous cell carcinoma (ESCC), and laryngeal squamous cell carcinoma (LSCC) in 490605 participants of the NIH-AARP Diet and Health Study cohort. Exposure to risk factors was obtained from the baseline questionnaire. GERD diagnosis was extracted among eligible participants via linkage to Medicare diagnoses codes and then multiply imputed for non–Medicare-eligible participants.

The study presented;
--Researchers accrued 931 cases of EADC, 876 cases of LSCC, and 301 cases of ESCC in this cohort and estimated multivariable-adjusted HRs of 2.23, 1.91, and 1.99 for EADC, LSCC, and ESCC, respectively.

--The associations were independent of sex, smoking status, alcohol intake, and follow-up time periods.

--They estimated that among the general population in the United States, 22.04% of people aged 50-71 years suffered from GERD.

--Using risk factor distributions for the United States from national survey data, 16.92% of LSCC cases and 17.32% of ESCC cases among individuals aged 50-71 years were estimated to be associated with GERD.

In conclusion, GERD is a common gastrointestinal disorder. Future studies may inform clinical surveillance of GERD patients and suggest new avenues for the prevention of these malignancies.