Gastrointestinal Myeloid Sarcoma- A rare case reported in NE
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Myeloid sarcoma is a malignant neoplasm of myeloid origin that locates outside the bone marrow.These patients usually present with nonspecific symptoms, including abdominal pain, nausea, vomiting, bowel obstruction or gastrointestinal bleeding without bone marrow involvement, thus being easily misdiagnosed.Most patients subsequently develop acute myelogenous leukemia (AML), and their prognosis is poor.

A 59-year-old man presented to the primary care clinic with a 3-month history of abdominal pain after eating. He had a history of immune thrombocytopenia and acute myeloid leukemia and had undergone allogeneic hematopoietic stem-cell transplantation 2 years before presentation.

Analysis of a bone marrow–biopsy sample performed 4 months before presentation had revealed 100% donor chimerism. Physical examination of the abdomen showed diffuse tenderness on deep palpation. Findings from laboratory studies included a white-cell count of 3640 per cubic millimeter, a hemoglobin level of 10.6 g per deciliter, and a platelet count of 16,000 per cubic millimeter.

Esophagogastroduodenoscopy was performed, and multiple polypoid masses were observed in the stomach and duodenum. A biopsy specimen was obtained, and histopathological findings were consistent with myeloid sarcoma; the diagnosis was confirmed by flow cytometry and immunohistochemical staining, which showed evidence of disease relapse.

Additional genetic testing revealed TP53 variants, which were detected in a previous bone marrow sample, and new somatic mutations with NF1 and ASXL1 variants. Myeloid sarcoma is a solid tumor manifestation of acute myeloid leukemia and can occur without blood or bone marrow disease. The patient started treatment with azacitidine and venetoclax at a local cancer center.

Source: https://www.nejm.org/doi/full/10.1056/NEJMicm2001235
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