Gene Mutation Behind Different Covid-19 Death Rates Among In
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Get authentic, real-time news that helps you fight COVID-19 better.
Install PlexusMD App for doctors. It's free.
Variation in a genetic mutation among Indians may be the main reason behind the difference in the death rates due to COVID-19 across various states of the country.

An international team, led by researchers at Banaras Hindu University (BHU) in Uttar Pradesh, analysed mutations in the gene responsible for the expression of the Angiotensin-Converting Enzyme 2 (ACE2), a protein on the surface of cells which is believed to act as a gateway for the novel coronavirus into the human body.

In the journal Frontiers in Genetics, the researchers looked at the frequency of this mutation described as rs2285666 haplotype among various states of India.

Their spatial analysis showed that in India, frequency of this haplotype, or a combination of mutations, varied between 33-100 per cent across different regions.

The researchers, for the first time, also ascertained a significant positive correlation for the mutation with the lower infection and case-fatality ratio (CFR) among Indian populations.

Gyaneshwer Chaubey, Professor at the Department of Zoology, BHU said the variations identified reduce the susceptibility of a person against the novel coronavirus.

"If in a region more people with this haplotype will be present, the infectiousness of the virus would likely be lesser," Chaubey, who led the study, told PTI.

The researchers noted that as far as policies to control the pandemic are concerned, the study suggests a single rule may not be effective in all the states.

"This unexpected info helped us to explore more about the mutations and haplotypes present among Indians. We found out that the rs2285666 associated haplotype increases the ACE2 expression," he said.

"In other words this mutation reduces the susceptibility against coronavirus," said Chaubey.