Gene Therapy for Overactive Bladder Shows Early Promise
A form of gene therapy led to clinically significant short-term improvement in women with longstanding overactive bladder (OAB), a preliminary placebo-controlled study showed.

After 12 weeks of follow-up, patients who received a single injection of either of two doses of URO-902 averaged 2.5 to 3 fewer micturitions daily versus patients who received a placebo injection. The average number of daily urgency episodes and episodes of urge urinary incontinence (UUI) declined by a similar degree.

In this prespecified 12-week analysis of a phase IIa trial of women with overactive bladder and urge urinary incontinence, a single dose of URO-902, at 24 and 48 mg, was associated with clinically relevant improvements in efficacy and, importantly, quality-of-life endpoints compared to placebo. Very importantly, this was very well tolerated. There were no significant adverse events.

Source: https://www.medpagetoday.com/meetingcoverage/aua/98735
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