Genetic Risk Assessment for Breast Cancer Using Multi-gene P
Multi-gene panel testing

Multi-gene panel testing encompasses tests for a wide range of mutations, including:
- Mutations in homologous recombination (HR) (BRCA1/2, ATM, BARD1, BRIP1, CHEK2, MRE11A, NBN, PALB2, RAD50, RAD51C, RAD51D)
- Mismatch repair genets (MLH1, MSH2, MSH6, PMS2 and EPCAM)
- Breast cancer susceptibility genes (CDH1, PTEN, STK11, TP53)
- Other cancer susceptibility genes

This is a highly cost-effective and time-effective method for the simultaneous evaluation of multiple genes. It has allowed for the identification of 40 to 50 percent more individuals with hereditary cancer gene mutations than is possible testing for BRCA1 and BRCA2 alone. However, these tests have some noteworthy limitations....