Genetics Not That Important in Pediatric Obesity: Study
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Five obesity-related single-nucleotide variants (SNVs) were linked with reductions in body weight or BMI in children on a lifestyle intervention for overweight and obesity, according to a genome-wide association study.

Genome-wide association studies have identified genetic loci influencing obesity risk in children. However, the importance of these loci in the associations with weight reduction through lifestyle interventions has not been investigated in large intervention trials. This study aimed to evaluate the associations between various obesity susceptibility loci and changes in body weight in children during an in-hospital, lifestyle intervention program.

Long-term Effects of Lifestyle Intervention in Obesity and Genetic Influence in Children (LOGIC), an interventional prospective cohort study, enrolled 1429 children with overweight or obesity to participate in an in-hospital lifestyle intervention program. Genotyping of 56 validated obesity single-nucleotide variants (SNVs) was performed, and the associations between the SNVs and body weight reduction during the intervention were evaluated using linear mixed-effects models for each SNV.

-- Of 1429 individuals enrolled in the LOGIC Study, 1198 individuals were genotyped.

-- A mean decrease was noted in body weight of 8.7 kg, and body mass index decreased by 3.3.

-- Five of 56 obesity SNVs were statistically significantly associated with a reduction of body weight or body mass index.

-- Compared with homozygous participants without the risk allele, homozygous carriers of the rs7164727 and rs12940622 risk alleles had a lower reduction of body weight, whereas carriers of the rs13201877, rs10733682, and rs2836754 risk alleles were associated with a greater reduction of body weight after adjustment for age and sex.

Conclusively, Genes appear to play a minor role in weight reduction by lifestyle in children with overweight or obesity. The findings suggest that environmental, social, and behavioral factors are more important to consider in obesity treatment strategies.