Genome Sequencing Helps Nail Virus Spread And Mutation
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As the new UK variant of coronavirus worries governments, India is keenly looking at the mutation in order to find out to what extent the altered virus can influence transmission, clinical outcomes, severity, and the need for specific public health intervention measures.

For genome sequencing, a swab sample collected through RT-PCR is used to amplify the virus. Genomic surveillance takes around 24 hours for a result, whereas analyzing or comparing with other strains to understand the change and impact takes up to two days.

“We need to detect all the 17 mutations to confirm the UK strain. For this, we have to map the whole genome of the virus and not just the spike gene. The UK variant has multiple mutations in different genes,” scientist Varsha Potdar, head of National Influenza Centre at the Indian Council of Medical Research-National Institute of Virology, said.

The study of accumulated mutations in the viral genomes enables comparison of virus samples and viral lineages in order to understand if local outbreaks are caused by the transmission of single or multiple viral lineages, experts said.

Source:
https://health.economictimes.indiatimes.com/news/diagnostics/genome-sequencing-helps-nail-virus-spread-mutation/80181426
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