Gestational Choriocarcinoma Presenting with Lacrimal Gland M
Gestational Trophoblastic Disease (GTD) is a spectrum of diseases characterized by abnormal proliferation of trophoblasts. There are five recognized clinicopathological subtypes, hydatidiform mole (complete or partial), invasive mole, gestational choriocarcinoma (GC), placental site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT).
The term Gestational Trophoblastic Neoplasia (GTN) is reserved for the last four in this subgroup as these have a propensity for progression, invasion, and metastasis any may potentially lead to death if untreated. GTN commonly develops following a hydatidiform mole and less commonly following a live birth or abortion.
Gestational choriocarcinoma is a malignant disease with marked trophoblastic hyperplasia resulting in direct invasion into the myometrium and endometrium. About 50% of these occur following a hydatidiform mole, with an incidence of 25% each after abortion or tubal pregnancy....