Gestational diabetes, HTN may worsen menopausal hot flashes:
Women diagnosed with gestational diabetes or preeclampsia are more likely to develop hot flashes during the menopause transition vs. women who are not diagnosed with those conditions, according to an analysis of the SWAN study presented at the North American Menopause Society annual meeting.

The researchers analyzed data from 2,249 women who completed a pregnancy history questionnaire at the 13th visit of the Study of Women’s Health Across the Nation (SWAN) study. Researchers stratified women as nulliparous, no hypertensive disorders of pregnancy or gestational diabetes, or having a history of hypertensive disorders of pregnancy or gestational diabetes.

Researchers assessed hot flashes at baseline and at each of the 13 follow-up visits over 15 years. Women who underwent hysterectomy/oophorectomy and those prescribed hormone therapy were excluded. Hot flash frequency was classified as any vs. none; 0 days, 1 to 5 days, or at least 6 days in the past 2 weeks.

Among women with previous gestational diabetes or hypertension, 176 (85%) had preeclampsia only, 27 women (13%) had gestational diabetes, and five women (2%) reported both conditions.

Researchers found that women in the preeclampsia and gestational diabetes group tended to have higher BMI, use antihypertensive and antidiabetes medications and had lower HDL levels vs. nulliparous women or women without gestational diabetes or preeclampsia. In age-adjusted models, compared with women with no preeclampsia or gestational diabetes, nulliparous women were 19% less likely to report any hot flashes, whereas women with preeclampsia and gestational diabetes were 20% more likely to report hot flashes.

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