Glaucoma-like Parapapillary Choroidal Microvasculature Dropo
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
A study was conducted to characterize peripapillary choroidal microvasculature dropout (MvD) in patients with compressive optic neuropathy (CON) as compared with those with open-angle glaucoma (OAG) using OCT angiography (OCTA).

Eighty-eight eyes of 44 patients with compressive optic neuropathy; 88 eyes of 88 patients with open-angle glaucoma matched by age, spherical error, and OCT-determined retinal nerve fiber layer thickness (RNFLT); and 88 eyes of 44 control participants matched by age and spherical error. Peripapillary microvasculature was evaluated, and peripapillary vessel density was measured in en face images segmented into inner-retinal and choroidal layers using swept-source OCTA. A microvasculature dropout was defined as a focal sectoral capillary dropout with no visible microvascular network in the choroidal layer.

Microvasculature dropout was observed in 30 eyes of 22 patients (50.0%) with compressive optic neuropathy, and in 48 eyes of 48 patients (54.5%) with open-angle glaucoma. All microvasculature dropouts in the compressive optic neuropathy group were located in the temporal parapapillary sector, whereas microvasculature dropouts in the open-angle glaucoma group were located in the temporal-inferior and temporal-superior sectors. At their locations, microvasculature dropouts in the compressive optic neuropathy group were accompanied by significant reductions in retinal vessel density and RNFLT, but this was not observed in the open-angle glaucoma group. The presence of microvasculature dropout was associated significantly with the female gender and thinner global retinal nerve fiber layer in the compressive optic neuropathy group, but not in the open-angle glaucoma group.

OCT angiography of the peripapillary area showed retinal and choroidal microvasculature impairment in patients with both compressive optic neuropathy and open-angle glaucoma. However, the features and associated characteristics of microvasculature dropout differed between these groups, suggesting that the pathogenesis of peripapillary microvascular impairment may be diverse.

Source:https://www.sciencedirect.com/science/article/abs/pii/S0161642020305170
Like
Comment
Share