Glioblastoma with signet ring cell morphology: A diagnostic
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The prototype glioblastoma (WHO Grade IV), the most frequent and malignant primary brain tumor, generally does not pose a diagnostic difficulty to the pathologist. Occasionally variations in the tumor morphology like epithelial/glandular structures, granular cells, lipidized cells, and very rarely, signet ring cell morphology do challenge the pathologist. Herein, we report a rare case of glioblastoma with signet ring cell morphology and underlie its importance so as to prevent an erroneous diagnosis of metastatic carcinoma.

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