Glucose not responsible for inflammation in type 2 diabetes,
While the underlying causes of inflammation in obesity and type 2 diabetes mellitus may not yet have been properly understood, a new research seems to have made a breakthrough by finding that the changes to mitochondria — the powerhouse of cells — drive chronic inflammation from cells exposed to certain types of fats, shattering the prevailing assumption that glucose was the culprit.

According to the study, chronic inflammation fuels many of the devastating complications of type 2 diabetes, including cardiovascular, kidney, periodontal diseases, and is thus one of the key targets for therapy development.

This new data may enlighten the conversation about tight glycemic control as the dominant treatment goal for people with diabetes.

“We exclusively used immune cells from human subjects for all of the work,” Barbara Nikolajczyk of UK Barnstable Brown Diabetes Center explained, noting that humans, but not animal models of type 2 diabetes, have the specific pro-inflammatory T cell profile her team had identified in earlier research.

The team was surprised to find that glycolysis wasn’t driving chronic inflammation. Instead, a combination of defects in mitochondria and elevated fat derivatives were responsible.

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