Glyburide as good as insulin in gestational diabetes
Women with GDM do not achieve blood sugar control alone with lifestyle modification and needs medication treatment. Oral agents, such as Glyburide have several advantages compared to insulin for GDM treatment.

In an population-based cohort study included GDM patients who required medication treatment. The study revealed 11,321 patients with GDM initiated glyburide or insulin during pregnancy 2007 to 2017. In multivariate models, the risk of neonatal respiratory distress was 2.03 per 100 births lower and the risk of NICU admission was 3.32 per 100 births lower after continuous admission to glyburide compared with insulin. There were no statistically significant difference s in glyburide vs insulin initiation in risk for neonatal hypoglycemia (0.85 per 100 births), jaundice (0.2 per 100 births), shoulder dystocia (-1.05 per 100 births), or large for gestational age categories (-2.75 per 100 births).

The study findings do not provide evidence of a difference in the outcomes examined between patients with GDM initiating glyburide compared with those initiating insulin.