Granular cell tumour (Abrikossoff’s tumour) of the tongue
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A 43-year-old female patient, with 1-year-old lesion on the tongue. The patient reported that the lesion was painless and slow growing. Physical examination revealed a firm, well-circumscribed whitish lesion of about 1.5 cm in diameter, located at the posterior limit of the middle third of the dorsum of the tongue. Thus, an incisional biopsy was performed, whose histological study revealed the diagnosis of granular cell tumour (GCT) in the dorsal region of the tongue.

Given the result, opted to perform an excisional biopsy under local anesthesia. The macroscopic sample had dimensions of 1.5×0.9×0.4 cm, with a whitish surface. Its anatomopathological study confirmed the diagnosis of GCT in the dorsal region of the tongue, and it also reported a submucosal lesion, consisting of proliferation of polygonal cells with large clarified granular cytoplasm Periodic acid–Schiff (PAS+), and with central, oval and monotonous nucleus. There was pseudoepitheliomatous hyperplasia (PH) of the lining. Regarding immunohistochemical analysis, the cells had marked and diffuse immunostaining for S100 protein. In the postoperative period, the patient evolved without intercurrences. There are no signs of recurrence of the lesion 1 year after the surgery.

GCT is an uncommon benign neoplasm that still reveals some controversial aspects. GCT can commonly occur in the oral cavity, particularly in the anterior part of the tongue.1 Also known as Abrikossoff’s tumor, is characteristically asymptomatic, with slow growth, and is often accidentally detected. It is characterized by the presence of a small, well-defined, submucosal nodular mass, about 1–3 cm in size, of firm consistency and usually covered by intact mucosa.