Granuloma annulare associated with diabetes, hyperlipidemia
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Diabetes and hyperlipidemia are both associated with granuloma annulare and may be risk factors for its development, according to a study.

Although granuloma annulare (GA) has been associated with several other conditions, these studies have been limited by single-center designs and small sample sizes.

This study aimed to evaluate whether there is an association between GA and type 2 diabetes, hyperlipidemia, autoimmune conditions, and hematologic malignant neoplasms, using a large population-based cohort study.

This retrospective cohort study used deidentified data from the US Optum Clinformatics Data Mart Database. A total of 5137 patients with GA were matched by age and sex with up to 10 randomly selected controls (n=51169) with a diagnosis of a nevus or seborrheic keratosis.

Logistic regression was used to evaluate for potential associations between GA and diabetes, hyperlipidemia, autoimmune conditions, and hematologic malignant neoplasms. All analyses were adjusted for race/ethnicity, income, and educational level.

Results:
-- This study included 5137 individuals with GA (3760 women; mean age, 57.7 years) and 51169 controls (37456 women; mean age, 57.7 years).

-- Those with GA were more likely than controls to have baseline diabetes (1086 vs 6780; adjusted odds ratio, 1.67), hyperlipidemia (1669 vs 14?553; aOR, 1.15), hypothyroidism (727 vs 5780; aOR, 1.24), and rheumatoid arthritis (62 vs 441; aOR, 1.34).

Those with GA were more likely to have incident diabetes (144 vs 1061; aOR, 1.31), hypothyroidism (41 vs 252; aOR, 1.59), systemic lupus erythematosus (21 vs 65; aOR, 3.06), and rheumatoid arthritis (26 vs 122; aOR, 2.05).

There was no association between GA and an increased risk of hematologic malignant neoplasms.

Conclusively, this population-based cohort study identified associations between GA and baseline diabetes and hyperlipidemia as well as between GA and both baseline and incident autoimmune conditions. These findings suggest that diabetes and hyperlipidemia may be risk factors for the development of GA and that autoimmunity may be an important factor in the pathogenesis of GA.

Source: https://jamanetwork.com/journals/jamadermatology/article-abstract/2780649
Like
Comment
Share