Gut environment changes due to androgen deprivation therapy
To study the changes in the gut microbiome by androgen deprivation therapy (ADT), this 24-week observational study investigated the relationship between testosterone levels and changes in gut microbiota in Japanese patients with prostate cancer undergoing ADT. In total, 23 patients completed the study. The - and ß-diversity of gut microbiota decreased significantly at 24 weeks after ADT. There was a significant positive correlation between the abundance of Proteobacteria, a known indicator of dysbiosis, and the concentration of lactate (R=0.49, p<0.01). The decline in testosterone levels resulted in detrimental changes in gut microbiota. This dysbiosis may contribute to an increase in frailty and an increased risk of adverse outcomes in patients with prostate cancer.