Gut health and mood are genetically intertwined: Study
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Researchers have confirmed a link between depression and stomach ulcers, in the world's largest study of genetic factors in peptic ulcer disease.

The research supported a holistic approach to caring for patients with gastrointestinal diseases like peptic ulcers, which affect between five and 10 percent of people at some time in their lives. Stress was thought to be the leading cause of peptic ulcer disease until it was linked to the bacteria H. pylori.

To identify why some people develop ulcers, investigators studied health data from 456327 individuals from the UK Biobank and identified eight genetic variations associated with the risk of getting peptic ulcer disease.

Six of the eight variations can be linked to why some people are more prone to H. pylori infection, which would make them more susceptible to peptic ulcer disease.

The professor said an existing peptic ulcer treatment targeted one of these genetic variations, so identifying other associated genes could offer opportunities for new treatments.

"If we can provide genetic risk scores to patients, it could be part of a prevention program to help reduce the rates of peptic ulcer disease," said the author.

Nature Communications
Source: https://doi.org/10.1038/s41467-021-21280-7
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