HER-2/neu-Directed Therapy for Rare Metastatic Epithelial Tu
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Human Epidermal Growth Factor Receptor 2 (HER-2)targeted therapy should be considered for tumors with HER-2 amplification. In our case series, we would like to emphasize this approach in other rare histologies. Specifically, our patient with extramammary Paget's disease of the scrotum represents the first reported case of a non-breast, non-gastric tumor with HER-2 overexpression with complete clinical and radiographic response to HER-2-targeted therapy....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924467/
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