HPV infection associated with increased risk for HIV acquisi
HPV infection was associated with an up to 2.6-fold increased risk for HIV acquisition among women in sub-Saharan Africa, according to study findings reported in AIDS.

Vaccine-preventable human papillomavirus (HPV) infection is common, especially in sub-Saharan Africa where HIV risk is also high. However, unlike other sexually transmitted infections (STIs), HPV's role in HIV acquisition is unclear. This study evaluated this relationship using data from MTN-003, a clinical trial of HIV chemoprophylaxis among cisgender women in sub-Saharan Africa.

Researchers matched 138 women who acquired HIV (cases) to 412 HIV-negative controls. Cervicovaginal swabs collected within 6 months before HIV seroconversion were tested for HPV DNA. They estimated the associations between carcinogenic (high-risk) and low-risk HPV types and types targeted by HPV vaccines and HIV acquisition, using conditional logistic regression models adjusted for time-varying sexual behaviors and other STIs.

Results:
-- Mean age was 23 (+/- 4) years. Any, high-risk, and low-risk HPV was detected in 84%, 74%, and 66% of cases, and 65%, 55%, and 48% of controls.

-- Infection with more than 2 HPV types was common in cases (67%) and controls (49%), as was infection with nonavalent vaccine-targeted types (60% and 42%).

-- HIV acquisition increased with any, high-risk, and low-risk HPV. Each additional type detected increased HIV risk by 20%.

-- HIV acquisition was associated with HPV types targeted by the nonavalent and quadrivalent vaccines.

Conclusively, HPV infection is associated with HIV acquisition in sub-Saharan African women. In addition to preventing HPV-associated cancers, increasing HPV vaccination coverage could potentially reduce HIV incidence.

Source: https://journals.lww.com/aidsonline/Abstract/9000/Prevalent_HPV_infection_increases_the_risk_of_HIV.96360.aspx
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