HRT could raise odds for asthma, finds study
Millions of women who take hormone replacement therapy (HRT) to ease their transition through menopause may be unknowingly upping their risk for asthma.

Investigators undertook a nested case-control study. A diagnosis of asthma was defined as two redeemed prescriptions of inhaled corticosteroids within 2 years. HRT was defined as two redeemed prescriptions of female sex hormones within 6 months. They included 34,533 women with asthma vs 345,116 women without asthma between 40 and 65 years of age.

- In a multivariate analysis adjusted for age, household income, and educational level, active HRT resulted in a hazard ratio (HR) of 1.63 of new asthma development.

- Women with asthma who terminated HRT were likely to discontinue their asthma treatment subsequently.

In Conclusion, HRT seems to play a role in the development of asthma in mature women. Clinicians prescribing HRT and women receiving HRT should be aware that new airway symptoms can develop, and discontinuation of HRT should be considered.