Happy Heart Syndrome: Takotsubo Syndrome Triggered by Positi
Of 2,482 patients in the registry, 910 patients (36.7%) exhibited an emotional trigger consisting of 873 “broken hearts” (95.9%) and 37 “happy hearts” (4.1%). Consequently, the prevalence of pleasant emotional triggers was 1.5% of all TTS cases. Compared with patients with TTS with negative preceding events, patients with happy heart syndrome were more frequently male (18.9% vs. 5.0%; p < 0.01) and had a higher prevalence of atypical ballooning patterns (27.0% vs. 12.5%; p = 0.01), particularly midventricular ballooning. In-hospital complications, including death, pulmonary edema, cardiogenic shock, or stroke (8.1% vs. 12.3%; p = 0.45), and long-term mortality rates (2.7% vs. 8.8%; p = 0.20) were similar in “happy hearts” and “broken hearts.” Happy heart syndrome is a rare type of TTS characterized by a higher prevalence of male patients and atypical nonapical ballooning compared with patients with negative emotional stressors. Despite similar short- and long-term outcomes in this study, additional data are needed to explore whether numerically lower event rates in “happy hearts” would be statistically significant in a larger sample size.

Source: https://www.acc.org/Latest-in-Cardiology/Journal-Scans/2022/06/28/19/24/Happy-Heart-Syndrome-Frequency