Healing Process with the use of a New Resorbable Synthetic M
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There is a vast amount of documented evidence in the literature regarding the safety and efficacy of the use of membranes in guided bone regeneration. The majority of the membranes available on the market are derived from collagen of animal origin, while a limited number of membranes are composed of synthetic polymers. The structure of membranes has evolved over time from a dense single layer to multiple layers having different porosities, which makes it possible to modulate their kinetics of resorption Resorbable membranes tend to be more advantageous than non-resorbable, for practical reasons and easiness to handle, lack of need for a second operation to remove the membrane, enhanced tissue integration, no need for a second operation to remove the membrane and smaller tendency for exposure. The aim of this study was therefore to specify the healing process of soft tissues over a four-week period using a synthetic resorbable membrane placement on oral sites. This retrospective study reports the healing process of soft tissues over a four-week period using synthetic absorbable membranes.

One-hundred and ten cases were included. Soft tissue healing was assessed from anonymized photographs, in accordance with the criteria of the Early Healing Index (EHI). At 1-week, 81% of the cases showed a Primary Closure (PC) when the membrane was not initially exposed. The score increased to 98% at 4-weeks. Healing at 1-week varied significantly according to the type of intervention, with 73% of primary closure for bone augmentation during implantation, versus 60% for bone augmentation before implantation and 46% for alveolar preservation. No statistically significant differences in the healing process were observed between the smoking and non-smoking groups.

This clinical study shows that the safety and exposure rates of this new synthetic membrane are comparable to the data gathered in the literature concerning non-cross-linked collagenous membranes. The soft tissue healing process when using a new synthetic absorbable PLGA membrane was evaluated in three different clinical indications. When the membrane was exposed, the membrane kept its integrity without any loss of the biomaterial granules and without infection. In most cases, the complete soft tissue healing occurred at 4-weeks in the absence of biological complications. This membrane finds its place among the absorbable membranes used in guided bone regeneration procedures by meeting the requirements of patients who – for ethical reasons – do not want medical devices of animal origin.

Source: https://opendentistryjournal.com/VOLUME/14/PAGE/450/FULLTEXT/
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