Health Ministry includes dexamethasone in revised COVID-19 t
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• Dexamethasone has been included in the treatment protocols for Covid-19 patients in moderate to severe stages of illness among other therapeutic measures by the Union health ministry on 27 June 2020.

• According to the revised ‘Clinical Management Protocols for Covid-19’, dexamethasone can be used as an alternative to methylprednisolone which already existed in the treatment guidelines.

• The revised treatment protocols for moderate cases advised considering methylprednisolone 0.5 to 1 mg/kg or dexamethasone 0.1 to 0.2 mg/kg for three days, preferably within 48 hours of admission or if oxygen requirement is increasing and if inflammatory markers are increased. The duration of administration should be reviewed as per the clinical response.

• For patients having respiratory distress requiring mechanical ventilation, both non- invasive and invasive, the ministry said methylprednisolone 1 – 2mg/kg/day or dexamethasone 0.2 to 0.4 mg/kg per day should be considered for 5-7 days in two divided doses, if not given already.

“Note that a larger dose of glucocorticoid will delay the removal of coronavirus due to immunosuppressive effects,” the treatment protocols stated.

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Steroids like dexamethasone or methyl prednisolone is used in many medical emergencies in high doses.The relevance of using in severe COVID19 is that the patient might have exhausted cortisone secretion due to severe stress of the disease.Usually in covid cortisone level is markedly elevated.
Jun 27, 2020Like1