Heart Failure May Not Be Causal Factor in Hepatorenal Syndro
This study included 87 patients with cirrhosis and 27 healthy controls in this prospective cohort study. The population comprised 27 patients with compensated cirrhosis and 60 with decompensated cirrhosis. Patients with compensated cirrhosis had higher azygos venous flow and higher hepatic artery flow fraction of cardiac index (CI) than controls, but other flow parameters were not significantly different. Decompensated patients had significantly higher cardiac index, higher superior mesenteric artery flow , and lower systemic vascular resistance compared to compensated patients. Patients with HRS-AKI had the highest cardiac output (CO) and lowest renal flow of all groups. Associations of single hemodynamic parameters were stronger to Model for End-Stage Liver Disease (MELD) than to portal pressure. The regional cardiocirculatory changes appear closely linked to clinical symptoms with three distinguished hemodynamic stages from compensated to decompensated cirrhosis and finally to HRS-AKI

Source: https://journals.lww.com/ajg/pages/articleviewer.aspx?year=9900&issue=00000&article=00390&type=Abstract
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