Hematological predictors of mortality in neonates with fulmi
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A Study was conducted to determine whether hematological and transfusion patterns following, the onset of NEC can identify infants likely to develop fulminant, fatal necrotizing enterocolitis (NEC).

Results:
--Of 336 neonates with NEC, 35 who developed fulminant NEC were born with higher birth weights and more frequently developed radiologically evident pneumoperitoneum and/or portal venous gas.

--Following the diagnosis of NEC, these infants were more likely to rapidly develop thrombocytopenia, lymphopenia, neutropenia, and lower total white blood cell counts compared to medical/surgical non-fulminant type.

--They were also more likely to have received a red blood cell (RBC) transfusion (76.7% vs. 53.1%) within 48?h after disease onset and platelet transfusion (24.2% vs. 11.7%) before the onset of NEC.

Conclusively, neonates with fulminant NEC frequently developed thrombocytopenia, lymphopenia, neutropenia, and leukopenia, received RBC transfusions after or platelet transfusions before the onset of NEC developed the fulminant disease.

Source: https://www.nature.com/articles/s41372-021-01044-3
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