Herceptin responsive lung adenocarcinoma in the setting of b
Case Report
A 70-year-old female ex-smoker was diagnosed with bilateral synchronous lung primaries during staging of a right-sided breast carcinoma. Computed tomography (CT) of the thorax revealed a 1.5 cm spiculated left upper lobe mass and a 1.2 cm right upper lobe nodule. Positron-emitted tomography (PET)-CT demonstrated no evidence of mediastinal or hilar lymphadenopathy [Figure 1]a and b. Core biopsies of the lung confirmed a left upper lobe squamous cell carcinoma positive for cytokeratin (CK) 5/6 and P63. The right upper lobe nodule was an adenocarcinoma that was thyroid transcription factor 1 (TTF-1), napsin, and CK-7 positive and CK-20 negative. The core biopsy of the breast demonstrated an infiltrating Grade II ductal carcinoma that was estrogen receptor positive, progesterone receptor negative, and Her-2 positive. Immunohistochemistry was CK-7 positive and CK-20, TTF-1, and napsin negative...

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