Herpes Zoster in an Immunocompetent Child without a History
Herpes zoster is a relatively rare infectious disease in the pediatric population, as compared with adults, which is due to the reactivation of latent Varicella Zoster virus. This was a 7-year-7-month-old immunocompetent boy with no past history of varicella, or chickenpox, or any other systemic diseases. He was born at a gestational age of 36 weeks via Caesarean section (C-section), due to a previous C-section with a maternal history of Gravida 3 Para 3. He received the varicella vaccine when he was 1-year old which was scheduled in the routine childhood vaccination program. The patient was brought to our emergency department on October 4, 2020, due to multiple vesicles and erythematous rashes over his right buttock and right lower leg after a three-day history of severe burning pain and tenderness, especially during the night, in his right leg. He was hemodynamically stable and had no fever or any neurologic abnormality. Based on the appearance of the patient’s cutaneous lesions, the patient was admitted to our pediatric ward on the same day.

Upon admission, the physical examination revealed numerous fine vesicles on an erythematous base, which distributed approximately around L3 and L4 dermatomes (Figure 1a,b). We noted an antalgic gait, and the patient experienced extensive pain in his right leg. Blood laboratory examinations indicated no leukopenia, leukocytosis, or an elevated C-reactive protein (CRP) level. Serologic screening for VZV antibodies (Ab) was also arranged which showed a positive result of VZV IgG Ab and a gray zone result of VZV IgM Ab.

Intravenous infusion of acyclovir 10 mg/kg/dose every 8 h and neurologic pain control with oral gabapentin 10 mg/kg/day every 8 h and ibuprofen 15 mg/kg/day every 6 h were prescribed on the first day of the admission. Though more clusters of vesicles appeared on the second and the third admission day, we kept the antiviral treatment throughout the entire clinical course. However, since the patient still complained about persistent burning pain, tightness in the anterior part of his right thigh, we replaced gabapentin with oral pregabalin. The patient also complained of some itching sensation over the vesicular lesions. After the fourth day of admission, the vesicular lesions gradually became dryer, darker and more crusted; no new skin lesions were observed. On 15 October, the twelfth admission day, the patient was discharged with the final diagnosis of herpes zoster. The patient visited our out-patient department for follow-up three weeks after he was discharged, and he no longer felt any pain in his right leg so that postherpetic neuralgia (PHN) was ruled out.

Source:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167658/
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