High Blood Sugar Linked To Depression Even In Non Diabetics-
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Higher levels of blood sugar or hyperglycemia are associated with depressive symptoms independent of lifestyle and cardiovascular risk factors, suggests a recent study in the journal Diabetologia. Further, the association between insulin resistance and depression was dependent on cardiovascular risk factors, specifically obesity.

Researchers used data from the longitudinal population-based Maastricht Study. They assessed hyperglycaemia by fasting and 2 h post-load OGTT glucose levels, HbA1c and skin autofluorescence (reflecting AGEs) at baseline. They used the Matsuda insulin sensitivity index and HOMA-IR to calculate insulin resistance at baseline. Depressive symptoms were assessed at baseline and annually over 4 years.

Key findings of the study include:

-- Fasting blood sugar, 2 h post-load glucose and HbA1c levels were associated with an increased risk for incident depressive symptoms after full adjustment.

-- Skin autofluorescence, insulin sensitivity index and HOMA-IR were not associated with an increased risk for incident depressive symptoms after full adjustment.

"These findings establish temporal association between hyperglycemia and incident depressive symptoms, supporting the concept that hyperglycemia itself is involved in the etiology of depression, and thus may provide a potential target for the prevention of depression in individuals with and without type 2 diabetes," concluded the authors.

Source: https://link.springer.com/article/10.1007/s00125-020-05247-9
Like
Comment
Share