High fasting blood sugar and central adiposity increase comp
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This study aimed to characterize diabetes subgroups among a multi-ethnic cohort and assess risk for incident complications.

Researchers included 1587 participants from the Multi-Ethnic Study of Atherosclerosis with diabetes. They characterized eight diabetes subgroups according to absolute thresholds for disease characteristics: age at diabetes diagnosis (less than 45 years), fasting glucose (FG greater than 7.7 mmol/L and 140 mg/dL), and waist circumference (women more than 105 cm; men more than 110 cm). They estimated risk for mortality, incident cardiovascular disease, chronic kidney disease, heart failure, dementia, and retinopathy, respectively, over 17 years after adjustment for demographics, behavioral, clinical risk factors, and cohort attrition.

Results:
-- The subgroup with both high FG and early age at onset was associated with higher risk for death, CVD, heart failure, CKD, and retinopathy and the subgroup with both early age at onset and high waist circumference was associated CVD, heart failure, CKD, and retinopathy.

-- The subgroup that met all three high-risk thresholds had greater risk for death, heart failure, CKD, and retinopathy.

-- They did not observe evidence for synergistic or antagonistic joint effects of the high-risk characteristics for any outcome.

Conclusively, this work supports differential risk for various diabetes complications among exclusive subgroups defined by age at diabetes onset, fasting glucose, and central adiposity.

Source: https://www.sciencedirect.com/science/article/abs/pii/S1056872721000891
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