High fractional exhaled nitric oxide levels in asthma patien
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Fractional exhaled nitric oxide (FeNO) is a biomarker for eosinophilic inflammation used for diagnosis and monitoring of asthma. High FeNO indicates (more than 80ppb) significant airway eosinophilia and steroid responsive airway inflammation.

The objective of this study is to investigate whether the extent of high FeNO levels correlates with clinical phenotype, asthma control, comorbidity, and pulmonary function test (PFT) findings in children with asthma.

Anthropometric data, daytime and nighttime symptoms, controller treatment, comorbidity, and PFT findings were retrieved from the Pediatric Pulmonology Unit database and correlated with FeNO levels in pediatric asthma patients with high FeNO levels.

Results:
--200 children and adolescents with high FeNO levels (range 36–227 ppb) were included. Within this range, higher FeNO levels positively correlated with increased daytime and nighttime symptoms and poorly controlled asthma.

--A FeNO level of more than 80 ppb was the cutoff for significantly more severe daytime and nighttime symptoms and very poorly controlled asthma compared with levels less than 80 ppb.

--No correlation was found between FeNO and controller treatment, comorbidity, and PFT performance.

Conclusively, In pediatric asthma patients, high FeNO levels correlates with increased symptom severity and poor asthma control. A FeNO level of more than 80 ppb may serve as an objective indicator for severe asthma.

Source: https://onlinelibrary.wiley.com/doi/10.1002/ppul.25333?af=R
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