High levels of bone turnover markers increase risk for all-c
Older men with higher concentrations of three bone turnover markers have a higher risk for all-cause mortality than those with lower concentrations. Higher mortality was seen in men who had higher concentrations of undercarboxylated osteocalcin, and also those with higher concentrations of two other bone turnover markers, procollagen type 1 N-propeptide and collagen type 1 C-terminal cross-linked telopeptide. Therefore, the underlying pathway appears to involve bone turnover, in general, and not specifically undercarboxylated osteocalcin. The results were similar even after excluding men who experienced bone fractures during follow-up, so there may be a broader effect of higher bone turnover to increase susceptibility to a range of conditions contributing to death.

Source: https://www.healio.com/news/endocrinology/20220712/high-levels-of-bone-turnover-markers-increase-risk-for-allcause-mortality-in-older-men
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