High serum copper levels may confer CVD mortality risk in me
Elevated serum copper levels were associated with CVD mortality risk in men, especially those with obesity, according to findings presented at the virtual American Society for Preventive Cardiology Congress on CVD Prevention.

To investigate whether elevated copper concentration was associated with risk for CVD mortality, researchers analyzed 1,911 Finnish men from the Kuopio Ischemic Heart Disease Study (mean age at baseline, 53 years), a database designed to assess various risk factors for CVD and other chronic diseases.

All participants had serum copper levels measured by an atomic absorption spectrometer (PerkinElmer). The men were stratified into quartiles by serum copper level — less than 1 mg/L, 1 to 1.1 mg/L, 1.1 to 1.21 mg/L and 1.21 mg/L — and into three groups by BMI — normal weight (less than 25 kg/m2), pre-obese (25 to 29.9 kg/m2) or obese ( 30 kg/m2).

During 26 years of follow-up, 358 men died from CVD, Isiozor said.

After controlling for age, BP, socioeconomic status, HDL, total cholesterol, smoking status, alcohol use and type 2 diabetes status, the researchers found that the risk for CVD mortality rose the higher the quartile of serum copper level a participant was in, regardless of BMI group, researchers said.

The risk was most pronounced in men with obesity (HR for quartile 4 vs. quartile 1 = 2.72; 95% CI, 1.28-5.76; P = .009; HR for quartile 3 vs. quartile 1 = 2.9; 95% CI, 1.36-6.19) and in men with pre-obesity (HR for quartile 4 vs. quartile 1 = 2.03; 95% CI, 1.29-3.2; HR for quartile 3 vs. quartile 1 = 2.26; 95% CI, 1.46-3.5), he said.

“Serum copper could possibly be a prognostic marker or a risk factor for cardiovascular disease mortality,” researchers said in the presentation. “The exact mechanism requires further study.”

Source: https://www.healio.com/news/cardiology/20210724/high-serum-copper-levels-may-confer-cvd-mortality-risk-in-men