Higher Coffee Intake Tied to Better Colorectal Cancer Outcom
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Higher coffee consumption may be associated with a reduced risk of disease progression and death in patients with advanced or metastatic colorectal cancer (CRC), a large cohort study found.

This prospective observational cohort study included 1171 patients with previously untreated locally advanced or metastatic colorectal cancer who were enrolled in Cancer and Leukemia Group B (Alliance)/SWOG 80405, a completed phase 3 clinical trial comparing the addition of cetuximab and/or bevacizumab to standard chemotherapy. Patients reported dietary intake using a semiquantitative food frequency questionnaire at the time of enrollment.

Results:
-- Among the 1171 patients included in the analysis, the median follow-up time among living patients was 5.4 years.
-- A total of 1092 patients (93%) had died or had disease progression.
-- Increased consumption of coffee was associated with decreased risk of cancer progression and death.
-- Participants who consumed 2 to 3 cups of coffee per day had a multivariable hazard ratio (HR) for Overall survival (OS) of 0.82 and for progression-free survival (PFS) of 0.82, compared with those who did not drink coffee.
-- Participants who consumed at least 4 cups of coffee per day had a multivariable HR for OS of 0.64 and for PFS of 0.78.
-- Significant associations were noted for both caffeinated and decaffeinated coffee.

Conclusively, Coffee consumption may be associated with reduced risk of disease progression and death in patients with advanced or metastatic colorectal cancer. Further research is warranted to elucidate underlying biological mechanisms.

Source: https://jamanetwork.com/journals/jamaoncology/article-abstract/2770262
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