Higher Dietary Acid Load Tied To HIgher Insulin Resistance
A population-based observational study including a sample of 545 individuals aged 25–64 years. All diet variables were obtained through two 24-h Food Recalls adjusted to obtain an estimate of habitual food consumption. DAL was measured by Potential Renal Acid Load (PRAL) and Net Endogenous Acid production (NEAP). Fasting blood samples were obtained from all participants. The primary outcome was IR, which was estimated by HOMA-IR. The mean PRAL and NEAP in the sample were 16.9 ± 4.8 and 66.1 ± 7.1 mEq/day, respectively. The average HOMA-IR score was 2.4 ± 1.6. In adjusted analyses, PRAL was positively associated with HOMA-IR, fasting insulin, and fasting blood glucose (p-value <0.05 in all cases), but not with HOMA- or glycated hemoglobin. NEAP also showed a direct–trend relationship with HOMA-IR and fasting insulin, but not with fasting blood glucose or the other outcomes. The strongest association was between PRAL and HOMA-IR (, 0.20; 95% CI, 0.06–0.35). A higher DAL was consistently associated with higher IR and insulin levels but not with other glycaemic parameters. Apparently, -pancreatic cell function is not affected by DAL in this population.

Source: https://clinicalnutritionespen.com/article/S2405-4577(22)00207-8/fulltext#