Researchers analyzed data from 49,694 participants in five consecutive NHANES cycles from 2009 to 2018, and from this cohort they examined data from 2746 people age 18 and older; had data for vitamin D3, fasting insulin, and fasting glucose; did not have diabetes, hypertension, hypercholesterolemia, or hyperuricemia; and met several other inclusion and exclusion criteria
They estimated insulin resistance using homeostasis model assessment of insulin resistance (HOMA-IR), which is equal to fasting insulin (U/mL) times fasting glucose (mmol/L) divided by 22.5. Insulin resistance was defined as HOMA-IR 2.6 and the absence of IR as HOMA-IR < 2.6.
862 participants had insulin resistance and 1884 participants did not have insulin resistance. Participants were an average age of 35 years old, and 44% were men. Median vitamin D3 level, measured by liquid chromatography-tandem mass spectrometry, was 50.9 nmol/L in those with insulin resistance and 58.5 nmol/L in those without insulin resistance.
In the fully adjusted multivariable model, patients had a significant 11% lower rate of prevalent insulin resistance for each 1-unit increase in serum vitamin D3.
Source: https://www.medscape.com/viewarticle/970875?src=rss
They estimated insulin resistance using homeostasis model assessment of insulin resistance (HOMA-IR), which is equal to fasting insulin (U/mL) times fasting glucose (mmol/L) divided by 22.5. Insulin resistance was defined as HOMA-IR 2.6 and the absence of IR as HOMA-IR < 2.6.
862 participants had insulin resistance and 1884 participants did not have insulin resistance. Participants were an average age of 35 years old, and 44% were men. Median vitamin D3 level, measured by liquid chromatography-tandem mass spectrometry, was 50.9 nmol/L in those with insulin resistance and 58.5 nmol/L in those without insulin resistance.
In the fully adjusted multivariable model, patients had a significant 11% lower rate of prevalent insulin resistance for each 1-unit increase in serum vitamin D3.
Source: https://www.medscape.com/viewarticle/970875?src=rss
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