Higher Vitamin D3 Levels Link to Less Insulin Resistance
Researchers analyzed data from 49,694 participants in five consecutive NHANES cycles from 2009 to 2018, and from this cohort they examined data from 2746 people age 18 and older; had data for vitamin D3, fasting insulin, and fasting glucose; did not have diabetes, hypertension, hypercholesterolemia, or hyperuricemia; and met several other inclusion and exclusion criteria

They estimated insulin resistance using homeostasis model assessment of insulin resistance (HOMA-IR), which is equal to fasting insulin (U/mL) times fasting glucose (mmol/L) divided by 22.5. Insulin resistance was defined as HOMA-IR 2.6 and the absence of IR as HOMA-IR < 2.6.

862 participants had insulin resistance and 1884 participants did not have insulin resistance. Participants were an average age of 35 years old, and 44% were men. Median vitamin D3 level, measured by liquid chromatography-tandem mass spectrometry, was 50.9 nmol/L in those with insulin resistance and 58.5 nmol/L in those without insulin resistance.

In the fully adjusted multivariable model, patients had a significant 11% lower rate of prevalent insulin resistance for each 1-unit increase in serum vitamin D3.

Source: https://www.medscape.com/viewarticle/970875?src=rss
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