Higher level of endometrial Indoleamine 2,3-dioxygenase expr
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Indoleamine 2,3-dioxygenase (IDO) has been reported to play a key role in placental development during normal pregnancy. However, the question of whether endometrial Indoleamine 2,3-dioxygenase expression affects in vitro fertilization (IVF) pregnancy outcomes remains unclear. The current study was undertaken to investigate whether there was any association between endometrial Indoleamine 2,3-dioxygenase immunohistochemical staining and in vitro fertilization treatment outcome. Findings suggested that an elevated level of endometrial Indoleamine 2,3-dioxygenase expression is associated with an increased rate of live birth in the in vitro fertilization treatment. The endometrial Indoleamine 2,3-dioxygenase expression may also be a new therapeutic target for better IVF treatment, however, further large prospective study is required to verify this hypothesis.

This retrospective study was designed to compare pregnancy outcomes among women with different endometrial Indoleamine 2,3-dioxygenase expression levels under their first IVF treatment. A total of 140 women undergoing their in vitro fertilization treatment were selected. Endometrial samples were collected during the mid-luteal phase before in vitro fertilization cycle. The endometrial Indoleamine 2,3-dioxygenase expression levels were analyzed by immunohistochemistry and compared between women who were pregnant or not. A logistic regression analysis was performed to determine the impact of endometrial Indoleamine 2,3-dioxygenase staining on live birth.

No significant differences in the endometrial Indoleamine 2,3-dioxygenase immunohistochemical staining were found between women who had clinical pregnancy and those who failed. However, the endometrial Indoleamine 2,3-dioxygenase staining was significantly higher among women who had live birth compared with those who had no live birth. Additionally, after adjusting for differences in maternal age, BMI, and duration of gonadotropin stimulation, women with higher Indoleamine 2,3-dioxygenase expression levels had an increased live birth rate.

Source:https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-020-03511-9
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