History of Dysplasia and Primary Site Associated with Recurr
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The recurrent disease occurs in a significant proportion of early-stage oral squamous cell carcinoma (OSCC) despite the removal of the entire tumor with clear surgical margins. Patients with more dysplasia and lesions present on the tongue and floor of the mouth showed higher recurrence.

The study by Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology seeks to identify clinicopathologic factors that increase the risk of locoregional recurrence in T1N0 OSCC.

Investigators conducted an observational retrospective analysis of 65 cases of T1N0 OSCC over a period of 13 years. For each case, they examined the clinical presentation, histopathologic appearance, and treatment characteristics of interest to evaluate the association between these variables and locoregional recurrence.

The 5-year and 10-year locoregional recurrence rates were 29.2% and 33.8%, respectively. Individuals with prior oral dysplasia experience significantly higher odds for locoregional recurrence and reduced 5-year disease-free survival rates. OSCC of the tongue and floor of mouth had lower recurrence odds compared to carcinomas of the gingiva, buccal mucosa, and palate. Histologic grade, depth of invasion, and elective neck dissection did not appear to influence locoregional recurrence for T1N0 tumors.

In particular, given the morbidity and mortality associated with OSCC, understanding of the clinicopathologic factors associated with the recurrent disease may lead to improved treatment and follow-up protocols for a subset of early-stage patients.

Source: https://doi.org/10.1016/j.oooo.2021.02.018
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