History of psychopathology as a risk factor for accelerated
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This study suggests that the prevention of psychopathology and monitoring of individuals with mental disorders for signs of accelerated aging may have the potential to reduce health inequalities and extend healthy lives.

Individuals with mental disorders are at an elevated risk of developing chronic age-related physical diseases. This study by JAMA Psychiatry was aimed to test the hypothesis that a history of psychopathology is associated with indicators of accelerated aging at midlife.

This prospective cohort study was based on the Dunedin Multidisciplinary Health and Development Study. Signs of aging (biological pace of aging; declines in sensory, motor, and cognitive functioning; and facial age) were assessed up to age 45 years using previously validated measures including biomarkers, clinical tests, and self-reports.

Of the original 1037 cohort participants, 997 were still alive at age 45 years, of whom 938 were assessed.

--Participants who had experienced more psychopathology exhibited a faster pace of biological aging; experienced more difficulties with hearing, vision, balance, and motor functioning; experienced more cognitive difficulties, and were rated as looking older.

--Associations persisted after controlling for sex, childhood health indicators, maltreatment, and socioeconomic status and after taking into account being overweight, smoking, use of antipsychotic medication, and the presence of physical disease.

--Tests of diagnostic specificity revealed that associations were generalizable across externalizing, internalizing, and thought disorders.

Conclusively, In this cohort study, a history of psychopathology was associated with accelerated aging at midlife, years before the typical onset of age-related diseases. This link is not specific to any particular disorder family but generalizes across disorders. Prevention of psychopathology and monitoring of individuals with mental disorders for signs of accelerated aging may have the potential to reduce health inequalities and extend healthy lives.

Source: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2776612
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