Hormonal changes during menopause are directly related to de
Menopause is unavoidable but it is possible that the negative metabolite shift can be diminished by eating healthily and being physically active. In particular, women should pay attention to the quality of fat in their diet and getting sufficient exercise to maintain cardiorespiratory fitness. HRT is an option that women should discuss with healthcare providers at this point in their lives.

The analysis included 218 perimenopausal women not using HRT at baseline. Levels of 180 metabolites (lipids, lipoproteins and amino acids) and two hormones (estradiol and FSH) were obtained from blood samples at baseline and every three to six months until early post menopause. The menopausal state was assessed using menstrual diaries and blood FSH levels. Early post menopause was defined as no periods for over six months and elevated FSH levels on at least two consecutive occasions. A total of 35 women (15%) started HRT during the study.

The average age at baseline was 51.7 years and the median follow up was 14 months. Menopause was associated with a statistically significant change in levels of 85 metabolites. An exploratory analysis showed that the menopausal hormonal shift directly explained the change in 64 of the 85 metabolites, with effect sizes ranging from 2.1% to 11.2%. These included low-density lipoprotein (LDL) cholesterol, triglycerides, fatty acids. and amino acids. The analyses were adjusted for age at baseline, duration of follow up, education level, smoking status, alcohol use, physical activity, and diet quality. A second exploratory analysis revealed that HRT was associated with increases in high-density lipoprotein (“good”) cholesterol and reductions in LDL (“bad”) cholesterol. Levels of bad cholesterol rise during menopause, and 10% of this increase is due to shifts in sex hormones.

Source: https://www.eurekalert.org/news-releases/952200
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