Hormone therapy may play role in development of asthma in wo
Hormone therapy with exogenous estrogen, with and without progesterone, may increase the risk for asthma in women, according to new research published in Chest.

Hormone replacement therapy (HRT) is prescribed to millions of women worldwide. Previous studies have suggested that HRT has both protective and harmful effects in asthma.

Researchers undertook a nested case-control study based on the Danish registers. A diagnosis of asthma was defined as two redeemed prescriptions of inhaled corticosteroids within 2 years. HRT was defined as two redeemed prescriptions of female sex hormones within 6 months. Data were analyzed using a conditional logistic regression model.

Results:
-- This study included 34,533 women with asthma vs 345,116 women without asthma between 40 and 65 years of age. In a multivariate analysis adjusted for age, household income, and educational level, active HRT resulted in a hazard ratio (HR) of 1.63 of new asthma development.

-- Women with asthma who terminated HRT were likely to discontinue their asthma treatment subsequently.

Conclusively, HRT seems to play a role in the development of asthma in mature women. Clinicians prescribing HRT and women receiving HRT should be aware that new airway symptoms can develop, and discontinuation of HRT should be considered.

Source: https://journal.chestnet.org/article/S0012-3692(21)00210-5/fulltext
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