How Common is Endometrial Cancer in Women with PMB?
As the worldwide burden of endometrial cancer continues to rise, interest is growing in the evaluation of early detection and prevention strategies among women at increased risk. Focusing efforts on women with postmenopausal bleeding (PMB), a common symptom of endometrial cancer, may be a useful strategy; however, PMB is not specific for endometrial cancer and is often caused by benign conditions.

A recently published meta-analysis in JAMA suggests that postmenopausal bleeding occurs in approximately 90% of women with endometrial cancer; however, only 9% of women with postmenopausal bleeding were diagnosed with endometrial cancer. These estimates varied by geographic region, hormone use, and calendar time.

The findings of the study signify that PMB is a common symptom among most women with endometrial cancer but most women with postmenopausal bleeding won’t be diagnosed with endometrial cancer.

These results can aid in the assessment of the potential clinical value of new early detection markers and clinical management strategies for endometrial cancer and will help to inform clinical and epidemiologic risk prediction models to support decision making.

Read more here: https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2695509
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