How The Immune System Can Be Better Used To Destroy Cancer C
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Scientists have gained new insight into how the immune system can be better used to find and kill cancer cells. The team has shown that antibodies, designed to target the molecule OX40, give a more active immune response when they bind closer to the cell membrane and can be modified to attack cancer in different ways.

OX40 is a co-receptor that helps to stimulate the production of helper and killer T-cells during an immune response. One of the ways cancer avoids detection is by suppressing immune responses to stop functional tumor-specific T-cells from being produced.

In the study, the researchers also discovered that switching the antibody's isotype, the part of the antibody that engages with cells of the immune system, could change the way the antibody worked.

When the mIgG2a isotype was used, the antibody could delete cells called Treg cells which are suppressive in the immune system. When the mIgG1 isotype was present, the antibody could stimulate killer T-cells to increase and therefore kill more cancer cells.

Source:
https://jitc.bmj.com/content/8/2/e001557
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