How is Gout is Different from Pseudogout ?
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Mitali Patil
How is Gout is Different from Pseudogout ?
Gout and pseudogout are arthritic diseases where crystalline deposits collect in the joints, leading to pain, stiffness, redness, and swelling. Although the symptoms of gout and pseudogout are similar, the underlying causes are different. The buildup of crystals in gout is triggered by elevated levels of uric acid, while pseudogout is caused by a buildup of calcium pyrophosphate dihydrate.

In general, men are more likely to suffer from gout, and women are very slightly more prone to pseudogout. Both conditions are common in the elderly, with pseudogout often affecting a knee, while gout usually affects a big toe.


1. Symptoms

Same: Both gout and pseudogout cause sudden, severe pain in one joint with little to no warning. The attacks can even be mistaken for life-threatening.

Different: Gout and pseudogout affect different joints. Half of all gout cases are in the big toe, and other common sites include the heel, fingertips, or wrist. Pseudogout most frequently affects the knee. It can also appear in the ankle, wrist, shoulder, or even hip.



2. Causes

Same: They're both caused by too much of a certain substance in the body, which crystallizes in a joint and causes pain.

Different: The problem-causing substances are different. Gout is caused by a buildup of uric acid. Pseudogout results from excessive calcium pyrophosphate, which is why some doctors refer to it as calcium pyrophosphate deposition (CPPD)


3. Risk factors

Same: Age, genetics, and previous injury in the affected joint are risk factors for both. Most initial gout episodes happen between ages 30 and 50; most people are diagnosed with pseudogout in their 60s. Risk is also greater for gout and pseudogout if you have a family history or have previously injured the affected joint.

Different: Gender and ethnicity affect risk for gout, but not for pseudogout. Men are more likely to have gout than women, and African-American men have greater gout risk than Caucasian men.


4. Treatment and prevention

Same: Both conditions are treated in the same manner: The pain of immediate attacks is relieved with rest, ice, and pain medications, and longer term solutions can include cortisone injections or possibly surgery.

Different: Gout attacks may be preventable with lifestyle changes, but pseudogout attacks aren't. To prevent a gout attack, people can avoid purines, which are found in alcohol, meats, fish, beans, and certain vegetables like asparagus and spinach. Weight loss and prescription medications may also help prevent gout attacks.
Dr. S●●●●●●●●●●●●a N●●k and 5 others like this
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