Hypereosinophilia in childhood acute lymphoblastic leukaemia
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Case :
A 13-year-old girl was referred in June 2011 to our Institution for persistent low-grade fever and fatigue. On admission, physical examination was negative except for noticeable swelling of the inferior left leg, that Doppler ultrasound documented to be secondary to deep venous thrombosis of the left iliac-femoral axis. Laboratory findings showed a normal leukocyte count (WBC 7,870/?L) with marked hypereosinophilia (44.3%), mild anemia (Hb 9.8 g/dL) and thrombocytopenia (129,000/?L). Peripheral blood smears revealed mature eosinophils and no abnormal cells. Main parasitic infections and allergic conditions were ruled out. Bone marrow aspirates showed a prevalence of FAB L2 lymphoblasts (52%) associated with 30% of eosinophilic elements. Immunophenotyping revealed CD10-positive blasts of B-lymphoid lineage, with cytogenetic analysis showing normal 46, XX karyotype. Molecular diagnostic studies detected clonal rearrangement of the immunoglobulin heavy-chain (IgH) region, while the main molecular leukaemic rearrangements, including bcr/abl, TEL/AML1, MLL/AF4, E2A-Pbx1, 4q FIP1L1/PDGFRA fusion genes, turned negative....

https://ijponline.biomedcentral.com/articles/10.1186/1824-7288-40-36
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Dr. N●●a D●●●●●●y
Dr. N●●a D●●●●●●y Pathology
Very nice case. eye opener too. eosinophilia should be investigated.
Apr 18, 2017Like