Hyperphosphatemia & Risks Of Kidney Injury & Mortality In Ho
Chronic kidney disease (CKD) is increasingly recognized as a public health problem and is associated with higher risks of cardiovascular disease and other conditions, including infections and cancer. Acute kidney injury (AKI) is a renal complication that occurs in up to 20% of hospital admissions, and which can eventually progression to CKD. Both AKI and CKD thus represent significant health burdens with potentially high morbidity and mortality rates.

Hyperphosphatemia has received considerable attention in the field of CKD - mineral and bone disorder (CKD-MBD) because of its association with cardiovascular morbidity and mortality. Even upper-normal serum phosphate levels could exacerbate the status of CKD, potentially leading to ESRD.

It was found that High phosphate intake disrupted endothelial function and thus affected maintenance of the glomerular filtration barrier. This impaired vasodilatation is known to be dependent on nitric oxide. The Ramipril Efficacy In Nephropathy (REIN) study conducted in patients with non-diabetic chronic nephropathies found that a 1 mg/dl increase in serum phosphate level was associated with a 85% excess risk of progression to ESRD.

Source: https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-019-1556-y