Hyperreflective Foci as Important Prognostic Indicators of P
A Study was conducted to investigate the presence and clinical relevance of hyperreflective foci (HRFs) in retinitis pigmentosa (RP).

77 RP cases were reviewed. The 10-mm wide cross-line macular scans in optical coherent tomography (OCT) were acquired. HRFs were classified according to the location in OCT: outer layers within the macula, macular border beyond the central 3 mm, and choroid. Visual acuity at baseline, at 12 months, and other fundus characteristics were collected.

Results:
--Mean LogMAR best-corrected visual acuity decreased from 0.59±0.66 to 0.74±0.81 in 1 year.

--66, 105, and 98 eyes were classified to HRF-outer-central, HRF-outer-perifoveal, and HRF-choroidal group, respectively.

--HRFs were positively correlated with poorer vision, central macular thinning, and ellipsoid zone disruption.

--Worse vision was associated with older age, macular involvement, and the coexistence of two or three HRF groups.

--HRFs developed more frequently in patients with thick choroid than in those with thin choroid.

--The coexistence of three HRF groups was correlated with quicker visual deterioration.

Conclusively, HRFs are prevalent in RP and can be a poor predictor of macular thickness and visual preservation. All types of HRFs, especially HRF-choroidal, were linked to thick choroid.

Source: https://journals.lww.com/retinajournal/Abstract/9000/Hyperreflective_foci_as_important_prognostic.95397.aspx
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